Madeleine S. Durkee

This study shows BRWD1 is essential for maintaining epigenetic states in germinal center B cells, affecting their function and subset identity.

This study shows that autoreactive B cells in rejecting kidney allografts produce pathogenic IgG independently of donor-specific antibodies, highlighting a novel mechanism in antibody-mediated rejection.

The paper uses high-dimensional spatial proteomics and a machine learning pipeline to identify and quantify disease-specific renal damage states in lupus nephritis and renal allograft rejection.

The paper introduces statistical tools to analyze immune cluster patterns in prostate cancer and finds high-grade tumors show more immune infiltration and active immune features.

The paper quantifies immune cell populations in lupus nephritis and renal allograft rejection using microscopy and computational tools, identifying distinct inflammatory trajectories.

This paper introduces pSAM, a method for analyzing high-plex immunofluorescence images, and shows it can generalize across different staining panels and tissues without manual annotation.