TRPM7 is a critical regulator of pancreatic endocrine development and high-fat diet-induced β-cell proliferation.
Molly K. Altman, Charles M. Schaub, Matthew T. Dickerson, Prasanna K. Dadi, Sarah M. Graff, Thomas J. Galletta, Gautami Amarnath, Ariel S. Thorson, Guoqiang Gu, David Aaron Jacobson
This paper identifies TRPM7's critical role in pancreatic progenitor expansion and β-cell proliferation under insulin-resistant conditions through genetic studies in mice.
bioRxiv · Jul 15, 2020 · PreprintDevelopmental Biology