Guoqiang Gu

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

The paper shows that insulin secretion from beta cells occurs at specific cortical sites within ELKS/LL5β patches that lack microtubules, suggesting microtubule absence is critical for secretion.

The paper shows that Myt3 translation is deregulated in β-cells under obesity-induced stress, leading to β-cell dysfunction and glucose intolerance.

This paper presents a method to image insulin secretion and granule dynamics in live pancreatic islets using Zn2+-binding dyes and TIRF microscopy, revealing distinct secretion behaviors of different insulin granule pools.

This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.

The paper shows that alpha cells regulate beta cell microtubule stability via Gcg and Glp1 signaling, affecting insulin secretion and creating functional heterogeneity in islets.

This study identifies St18 as a transcriptional determinant specifying projection neuron identity in the MGE lineage and shows its role in regulating migration and morphology of GPe neurons.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This paper identifies TRPM7's critical role in pancreatic progenitor expansion and β-cell proliferation under insulin-resistant conditions through genetic studies in mice.

This study shows that Myt transcription factors prevent over-activation of stress-response genes in pancreatic β cells, maintaining their function and survival.

This paper introduces sc-UniFrac, a framework to quantify compositional diversity in cell populations across single-cell transcriptome datasets, demonstrating its utility in various applications.