Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells
Abhrajit Ganguly, Cynthia M. Carter, Aristides Rivera Negron, Hua Zhong, Alvaro G. Moreira, Matthew S. Walters, Lynette Kay Rogers, Y. S. Prakash, Trent E. Tipple, Arlan Richardson
This study shows that hyperoxia impairs mitochondrial function and epithelial differentiation in neonatal airway cells through proteomic analysis and metabolic reprogramming.
American Journal of Physiology-Lung Cellular and Molecular Physiology · Dec 5, 2025Peer-reviewedDevelopmental Biology