3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells
Abhrajit Ganguly, Cynthia M. Carter, Aristides Rivera Negron, Paul T. Pierce, Lynette Kay Rogers, Matthew S. Walters, Y. S. Prakash, Trent E. Tipple, Arlan G Richardson
This study shows that MPST is essential for maintaining mitochondrial metabolic integrity in neonatal airway epithelial cells, and its loss under hyperoxia disrupts epithelial differentiation and contributes to airway injury.
American Journal of Physiology-Lung Cellular and Molecular Physiology · Mar 28, 2026Peer-reviewedDevelopmental Biology