Fine-tuning mechanical constraints uncouples patterning and gene expression in murine pseudo-embryos
Judith Pineau, Jérôme Wong-Ng, Alexandre Mayran, Lucille Lopez‐Delisle, Pierre Osteil, Armin Shoushtarizadeh, Denis Duboule, Samy Gobaa, Thomas Gregor
This study shows that mechanical constraints can separately affect patterning and gene expression in murine gastruloids, revealing distinct cellular responses to external forces.
bioRxiv · Jan 28, 2025 · PreprintDevelopmental Biology