Alexandre Mayran

This paper introduces a dual-gastruloid model to study the co-development of foregut-pharyngeal mesoderm in mice, showing the role of Foxa2 in Tbx1 expression.

This study shows that mouse gastruloids lacking all HOX function can elongate but fail to form endoderm and properly segment mesoderm, suggesting HOX proteins are needed to posteriorize anterior structures.

This study identifies early transcriptional targets of WNT signaling during limb bud and digit development by transiently blocking WNT signaling with small molecule inhibitors.

This study shows that mechanical constraints can separately affect patterning and gene expression in murine gastruloids, revealing distinct cellular responses to external forces.

This study shows that Nodal and Wnt signalling act antagonistically during mammalian gastrulation, with Nodal promoting anterior structures and Wnt driving posterior development.

This study shows that physical size affects morphogenetic timing and outcomes in gastruloids, while transcriptional programs remain stable, with extreme sizes showing distinct gene expression patterns.

The paper investigates how CTCF sites in a DNA spacer delay Hoxb13 activation, affecting tail length by modulating its heterochronic expression.

This study identifies a Cadherin switch mechanism that regulates self-organization in gastruloids by linking pluripotency exit and cell differentiation.

The paper shows that PRC2 inactivation has minimal effect on PRC1 occupancy in developing limbs, highlighting the critical role of PRC2-independent PRC1 in gene regulation during limb development.

This study shows that Pax7's pioneer action on heterochromatin requires both DNA binding domains, while low affinity binding only needs the paired domain.

The paper analyzes PRC1 and PRC2 binding dynamics during limb development, finding that many PRC-bound promoters are occupied exclusively by PRC1, independent of PRC2.

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.

The paper shows that pioneer factor Pax7 and nonpioneer factor Tpit cooperate to open chromatin in melanotrope cells, with Pax7 recognizing heterochromatin and Tpit enabling chromatin opening.

This study identifies Creb3l2 as a transcription factor that scales translation capacity in secretory cells by directly regulating translation effector genes.