Pierre Osteil

This study shows Netrin-1 supports naive pluripotency in hESCs by modulating epigenetic and signaling pathways, with effects dependent on culture conditions.

The paper shows that activating MIXL1 in hiPSCs improves endoderm differentiation and maturation.

The paper identifies mesendoderm progenitor cells in mouse embryos and shows their contribution to endoderm and mesoderm lineages through lineage tracing and analysis of Mixl1 function.

This study shows that mechanical constraints can separately affect patterning and gene expression in murine gastruloids, revealing distinct cellular responses to external forces.

The paper investigates how CTCF sites in a DNA spacer delay Hoxb13 activation, affecting tail length by modulating its heterochronic expression.

This study identifies a Cadherin switch mechanism that regulates self-organization in gastruloids by linking pluripotency exit and cell differentiation.

The paper compares replication stress management in naive and primed pluripotent mouse cells, finding that primed cells use Atr to prevent genomic damage, while naive cells activate Atm and undergo apoptosis.

The paper identifies a TWIST1-chromatin regulatory module critical for neural crest cell differentiation and craniofacial patterning through protein interaction and perturbation studies.

This study identifies TWIST1 homodimers and heterodimers with E-proteins as key regulators of lineage-specific differentiation, revealing their distinct roles in mesoderm, neural crest, and endoderm development.

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.