Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants
Tyrone DeSpenza, Emre Kiziltug, Garrett Allington, Daniel G. Barson, David A. O’Connor, Stephanie M. Robert, Kedous Y. Mekbib, Pranav Nanda, Ana B.W. Greenberg, Amrita Singh, Phan Q. Duy, Francesca Mandino, Shujuan Zhao, Anna Y. Lynn, Benjamin C. Reeves, , Kristopher Thomas Kahle
This study shows PTEN mutations cause ventriculomegaly and cortical network dysfunction through neural precursor and interneuron dysregulation, with mTORC1 inhibition offering therapeutic potential.
bioRxiv · Mar 18, 2023 · PreprintNeuroscience