Bryan W. Luikart

Nuclear-excluded PTEN rescued all knockout overgrowth phenotypes in mouse dentate granule neurons; nuclear-restricted PTEN rescued only spine head area and partly soma size, so localization shapes function.

This study shows PTEN regulates neuronal growth and excitability through distinct mTORC1 and mTORC2 pathways, with implications for ASD and epilepsy.

This study shows that LSD pretreatment enhances the lasting effects of brain stimulation on neural activity in rats.

This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.

The paper shows that Kit Ligand and Kit receptor maintain synaptic inhibition in Purkinje Cells through their expression in specific neuronal populations.

The paper benchmarks PIPseq, a single-cell RNA sequencing method, across different scales and models, showing its ability to detect cell types and differentially expressed genes.

This study shows PTEN mutations cause ventriculomegaly and cortical network dysfunction through neural precursor and interneuron dysregulation, with mTORC1 inhibition offering therapeutic potential.

The paper uses scRNA-seq to study gene expression changes in conditional Pten knockout mouse neurons, identifying altered gene expression patterns.