PTEN Subcellular Localization Dictates Function
Nicole M. Desmet, Cheyenne F. Griffin, H. Nephi Seo, Annaliese OuYang, Penelope Tir, Mackenzi L. Prina, Wei Wang, Meijie Li, Bryan W. Luikart
Nuclear-excluded PTEN rescued all knockout overgrowth phenotypes in mouse dentate granule neurons; nuclear-restricted PTEN rescued only spine head area and partly soma size, so localization shapes function.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience✦ In-depth digest