Computed atlas of the human GPCR-G protein signaling complexes
Pasquale Miglionico, Marin Matic, Luca Franchini, Hiroki Arai, Lorenzo Amir Nemati Fard, Arora Chakit, Magda Gherghinescu, Natalia De Oliveira Rosa, Ryoji Kise, Jorge Silvio Gutkind, Cesare Orlandi, Asuka Inoue, Raimondi Francesco
This study predicts 3D structures of human GPCR-G protein complexes using AlphaFold3 and uses machine learning to predict coupling potency, revealing new signaling mechanisms and coupling preferences across GPCR subtypes.
bioRxiv · Mar 10, 2026 · PreprintBioinformatics