Luca Franchini

Computed atlas of the human GPCR-G protein signaling complexes

This study predicts 3D structures of human GPCR-G protein complexes using AlphaFold3 and uses machine learning to predict coupling potency, revealing new signaling mechanisms and coupling preferences across GPCR subtypes.

Omega-3 Fatty Acid Derived Neuroactive Lipids - Docosahexaenoyl-Glycine and Its Epoxide Metabolites are Multifunctional Lipid Mediators

The paper identifies NA-Gly, DHA-Gly, and their epoxide derivatives as multifunctional lipid mediators with anti-inflammatory properties and selective receptor modulation, suggesting therapeutic potential for neuroinflammation.

Go/z-biased coupling profile of the dopamine D3 receptor

The paper investigates the G protein coupling profile of dopamine D3 receptor, finding it selectively activates Go and Gz subtypes but not Gi proteins, with structural determinants identified.

Gz Enhanced Signal Transduction assaY (GZESTY) for GPCR deorphanization

GZESTY is a cell-based assay for Gi/o/z-coupled GPCRs that detects ligand activation and identifies endogenous ligands for orphan GPCRs.