Ryoji Kise

The paper studies the behavior of human RTKs using single-molecule imaging and finds that molecular behavior correlates with cell growth regulation.

This paper develops a NanoBiT-based platform to systematically study multiple layers of GPCR signaling in living cells.

This study predicts 3D structures of human GPCR-G protein complexes using AlphaFold3 and uses machine learning to predict coupling potency, revealing new signaling mechanisms and coupling preferences across GPCR subtypes.

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.