An autoinhibitory regulatory switch governs heterotypic phase separation and liquid-to-solid phase transition of TDP-43 and tau into cytotoxic amyloids
Anuja Walimbe, Snehasis Sarkar, Roopali Khanna, Arpita Singh, Deepti D. Ramteke, Ashish Joshi, Samrat Mukhopadhyay
The paper investigates how TDP-43 and tau undergo heterotypic phase separation and transition into cytotoxic amyloids, revealing an autoinhibitory switch that regulates this process.
bioRxiv · May 27, 2026 · PreprintBiophysics