Samrat Mukhopadhyay

The paper investigates how TDP-43 and tau undergo heterotypic phase separation and transition into cytotoxic amyloids, revealing an autoinhibitory switch that regulates this process.

This study shows that PfHP1 phase separation controls var gene silencing in P. falciparum by forming heterochromatin clusters, leading to antigenic variation.

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

This study shows that Ydj1, an Hsp40, prevents amyloid formation of the Y145Stop prion protein variant through heterotypic phase separation.

This study uses homoFRET to measure material property changes in biomolecular condensates, showing how factors like RNA and post-translational modifications affect their structure.