Ashish Joshi

The paper investigates how TDP-43 and tau undergo heterotypic phase separation and transition into cytotoxic amyloids, revealing an autoinhibitory switch that regulates this process.

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

This study uses homoFRET to measure material property changes in biomolecular condensates, showing how factors like RNA and post-translational modifications affect their structure.