A Computational Model of Tumor Interactions with Bone-Resident Cells Predicts Tumor-Type-Specific Responses to Perturbations
Alexandra Gutierrez Vega, Natalie E. Bennett, Erik P. Beadle, Saja Alshafeay, Ramcharan Chitturi, Anishka Nagarimadugu, Hrishikesh Villur, Arsh Jaiswal, Julie A. Rhoades Sterling, L. Lynn Harris
This paper develops a computational model of tumor-bone interactions to predict how different tumor types respond to perturbations, showing that bone-adapted tumors are less dependent on bone-derived growth factors and less responsive to OC-targeted therapy.
bioRxiv · Mar 19, 2026 · PreprintSystems Biology