Natalie E. Bennett

A Computational Model of Tumor Interactions with Bone-Resident Cells Predicts Tumor-Type-Specific Responses to Perturbations

This paper develops a computational model of tumor-bone interactions to predict how different tumor types respond to perturbations, showing that bone-adapted tumors are less dependent on bone-derived growth factors and less responsive to OC-targeted therapy.

Gli2 Overexpression Alters the Differentiation Status of Dedifferentiated Liposarcoma Cells and Results in an Immunosuppressive Myeloid Phenotype in Orthotopic Tumors

This study shows that Gli2 overexpression in dedifferentiated liposarcoma cells reduces adipogenic differentiation, increases osteoblast markers, and promotes an immunosuppressive myeloid phenotype in tumors.