KIF18A Inhibition as a Therapeutic Strategy in Cancers with Rb Pathway Inactivation
Celia Andreu, Arshi Arora, Song Chen, Chaithanya P. Vedula, Adriana Roopnariane, Sarah E. Bettigole, Nazario Bosco, Aamir Dohadwala, the SOVI-2302 Investigators, The VLS-1488-2201 Investigators, David Southwell, Neil J. Ganem, Timothy Geoffrey Bowler, Samuel F. W. Bakhoum
This paper identifies p16INK4a expression as a predictive biomarker for KIF18A inhibitor response in cancers with Rb pathway inactivation, showing higher response rates and longer progression-free survival in p16INK4a-high tumors.
bioRxiv · Apr 20, 2026 · PreprintCancer Biology