Author

Nazario Bosco

NYU Langone Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Cancer Biology· 1 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Teresa DavoliiD· 3 shared Jef D. BoekeiD· 2 shared LESLIE ANN MITCHELLiD· 2 shared Ran BroshiD· 2 shared Aamir Dohadwala· 1 shared Adriana Roopnariane· 1 shared Aleah GoldbergiD· 1 shared Aleksandra M. WudzinskaiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Teresa DavoliORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

KIF18A Inhibition as a Therapeutic Strategy in Cancers with Rb Pathway Inactivation

Celia Andreu, Arshi Arora, Song Chen, Chaithanya P. Vedula, Adriana Roopnariane, Sarah E. Bettigole, Nazario Bosco, Aamir Dohadwala, the SOVI-2302 Investigators, The VLS-1488-2201 Investigators, David Southwell, Neil J. Ganem, Timothy Geoffrey Bowler, Samuel F. W. Bakhoum

This paper identifies p16INK4a expression as a predictive biomarker for KIF18A inhibitor response in cancers with Rb pathway inactivation, showing higher response rates and longer progression-free survival in p16INK4a-high tumors.

bioRxiv · Apr 20, 2026 · PreprintCancer Biology

KaryoTap Enables Cost-Effective High-Throughput Single-Cell Aneuploidy Profiling and Reveals How Positive and Negative Selection Shapes Cancer Genomes

Joseph C. Mays, Fabio Alfieri, Maria Trifas, Manjunatha Kogenaru, Helberth M. Quysbertf, Sally Mei, Nazario Bosco, Xin Zhao, Joy J. Bianchi, Aleah Goldberg, Gururaj Rao Kidiyoor, Liam J. Holt, David Fenyö, Teresa Davoli

KaryoTap enables high-throughput single-cell aneuploidy profiling, revealing that positive and negative selection shape cancer genomes by influencing chromosomal gains and losses.

bioRxiv · Sep 8, 2023 · PreprintGenomics

Germline Transmission of a Circular Human Artificial Chromosome in the Mouse

Aleksandra M. Wudzinska, LESLIE ANN MITCHELL, Ran Brosh, Nazario Bosco, Francesco E. Boccalatte, Iannis Aifantis, Sang Yong Kim, Teresa Davoli, Jef D. Boeke

This study demonstrates that a circular human artificial chromosome can be transmitted through three generations of mice without health or reproductive issues.

bioRxiv · Jun 22, 2022 · PreprintSynthetic Biology

Structural variant evolution after telomere crisis

Sally M. Dewhurst, Xiaotong Yao, Joel A. Rosiene, Huasong Tian, Julie M. Behr, Nazario Bosco, Kaori Takai, Titia de Lange, Marcin B. Imielinski

The paper investigates structural variants (SVs) generated during telomere crisis, showing that BFB cycles and chromothripsis can occur in clones that escape telomere crisis.

Nature Communications · Apr 7, 2021Peer-reviewedGenomics

De novo assembly, delivery and expression of a 101 kb human gene in mouse cells

LESLIE ANN MITCHELL, Laura H. McCulloch, Sudarshan Pinglay, Henri Berger, Nazario Bosco, Ran Brosh, Milica Bulajić, Emily Huang, Megan S. Hogan, James A. Martin, Esteban O. Mazzoni, Teresa Davoli, Matthew T. Maurano, Jef D. Boeke

The paper describes a pipeline for de novo assembly, delivery, and expression of a 101 kb human gene in mouse cells, demonstrating functional evaluation of a full-length gene.

bioRxiv · Jan 26, 2019 · PreprintGenetics