Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer
Janith A. Seneviratne, Clare L Crisp, Eleanor Glancy, Natalie Choy, Winnie Tan, Matthew Neve, Melanie Stammers, Tongtong Wang, Ruby Johnstone, Arshnoor Kaur, Katie A. Fennell, Marian L. Burr, Benjamin L. Parker, Shabih Shakeel, Mélanie A. Eckersley-Maslin
The paper shows DPPA2/4 in NSCLC create a unique chromatin state by uncoupling PRC complex recruitment from activity, promoting tumourigenesis.
bioRxiv · Apr 27, 2025 · PreprintMolecular Biology