Mélanie A. Eckersley-Maslin

The paper identifies early embryonic gene expression programs in cancer and shows their stage-dependent impact on patient survival.

The paper shows DPPA2/4 in NSCLC create a unique chromatin state by uncoupling PRC complex recruitment from activity, promoting tumourigenesis.

This study shows XCI erosion in female hiPSCs is common, heterogeneous, and persists during differentiation, affecting X-linked gene expression without altering DNA methylation levels.

The paper introduces a low-input sequential ChIP method to map bivalent chromatin with high resolution and detects more bivalent regions in mouse embryonic stem cells.

This study shows that maternal SMARCA5 is essential for major ZGA in mouse embryos by regulating promoter and distal regulatory region accessibility and nucleosome positioning.

The paper examines genomic imprinting and X-chromosome inactivation stability in aging mouse brains, finding they remain largely stable despite epigenetic drift.

This study shows Dppa2/4 are not required for zygotic genome activation but are important for offspring survival, as maternal depletion leads to reduced litter size and increased preweaning lethality.

The paper shows that donor cell sex and reprogramming conditions affect imprinting defects in mouse iPSCs, with distinct methylation patterns observed under different culture conditions.

IMPLICON is a high-throughput method for measuring DNA methylation at imprinted regions with high coverage and resolution, validated in mice and adapted for human use to detect imprinting errors.

The paper uses CRISPR-activation and single-cell RNA-seq to identify 44 epigenetic regulators that induce a zygotic genome activation-like state in mouse embryonic stem cells.

This study identifies Dppa2/4 as epigenetic factors that establish bivalency at developmental promoters, enabling lineage commitment by maintaining poised RNA polymerase and preventing DNA methylation.

This study identifies Dppa2 and Dppa4 as upstream regulators of the Dux-driven zygotic transcriptional programme in 2C-like cells.

This paper shows TET3 promotes open chromatin and enhances global transcription in embryonic stem cells, independent of its catalytic activity.

This paper establishes expanded potential stem cells (EPSCs) from mouse blastomeres and shows they can contribute to both embryo proper and trophoblasts in chimeras.