Shabih Shakeel

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

This study identifies EGF7 in PfRipr as a critical domain for inhibiting Plasmodium falciparum erythrocyte invasion and provides a basis for vaccine design.

PartiNet improves particle picking in cryo-EM with a dynamic neural network that adapts to micrograph quality, enhancing efficiency and particle yield without sacrificing accuracy.

This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

The paper shows DPPA2/4 in NSCLC create a unique chromatin state by uncoupling PRC complex recruitment from activity, promoting tumourigenesis.

This paper improves crosslinking mass spectrometry by using diazirine-based photo-crosslinking to better study dynamic protein regions and their conformational changes.

This paper determines the structure of FANCD2-FANCI (D2-I) using cryoEM, showing that monoubiquitination stabilizes its closed conformation on DNA, acting as a clamp for DNA crosslink repair.