Winnie Tan

PartiNet improves particle picking in cryo-EM with a dynamic neural network that adapts to micrograph quality, enhancing efficiency and particle yield without sacrificing accuracy.

This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

The paper shows DPPA2/4 in NSCLC create a unique chromatin state by uncoupling PRC complex recruitment from activity, promoting tumourigenesis.

The paper correlates clinical severity in Fanconi anemia with residual function of FANCB missense variants through biochemical and cell-based assays.