An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS
Olivia Gautier, Jacob A. Blum, Thao P. Nguyen, Sandy L. Klemm, Mai Yamakawa, Nasa Sinnott-Armstrong, Yi Zeng, Chung-ha O. Davis, Juliane Bombosch, Lisa Nakayama, Kevin A. Guttenplan, Derek C. Chen, Arwa Kathira, Luke Zhao, Jessica E. Rexach, , Aaron D. Gitler
The paper identifies a disease-associated motor neuron state in a mouse ALS model that precedes cell death and links it to human ALS genetic risk factors.
bioRxiv · Aug 21, 2025 · PreprintNeuroscience