Decoding epitope immunodominance in HIV Env using cryoEM and machine learning
Jan S. Schuhmacher, Shuhao Xiao, Elise Eray, Sharidan Brown, Alexander P. Zambrowski, Aryan Jain, Daniel Montiel-Garcia, Gabriel Ozorowski, Wenwen Zhu, Katrina Saam, Tom G. Caniels, John P. Moore, Max Crispin, Rogier W. Sanders, Srirupa Chakraborty, , Aleksandar Antanasijevic
This study uses cryoEM and machine learning to predict and redirect immunodominant epitopes in HIV Env, showing improved vaccine antigen design.
bioRxiv · Mar 11, 2026 · PreprintImmunology