Author

John P. Moore

Cornell UniversityORCID 0000-0002-9902-6096Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Andrew B. WardiD· 4 shared Rogier W. SandersiD· 4 shared Gabriel OzorowskiiD· 3 shared Per Johan KlasseiD· 3 shared Albert CupoiD· 2 shared Aleksandar AntanasijeviciD· 2 shared Anila YasmeeniD· 2 shared David C. MontefioriiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

Andrew B. WardORCID

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Author profile →

4 papers

Recent·Most cited

Sequential vaccination matures VRC01-class HIV-1 neutralizing antibodies in humans

Tom G. Caniels, Madhu S. Prabhakaran, Sashank Agrawal, Kellie J. MacPhee, Rhianna Bronson, Weiwei Wu, Eva I.M. Schumacher, Swastik Phulera, Katrina G. Millard, Deanna Dong, Martina Turroja, Aimee A. Desrosiers, Jeffrey Michael Bethony, Elissa M. Malkin, Annelou van der Veen, , Rogier W. Sanders

This study shows that sequential vaccination can mature VRC01-class B cells into antibodies that neutralize a broad range of HIV-1 viruses.

bioRxiv · Oct 26, 2026 · PreprintImmunology

Decoding epitope immunodominance in HIV Env using cryoEM and machine learning

Jan S. Schuhmacher, Shuhao Xiao, Elise Eray, Sharidan Brown, Alexander P. Zambrowski, Aryan Jain, Daniel Montiel-Garcia, Gabriel Ozorowski, Wenwen Zhu, Katrina Saam, Tom G. Caniels, John P. Moore, Max Crispin, Rogier W. Sanders, Srirupa Chakraborty, , Aleksandar Antanasijevic

This study uses cryoEM and machine learning to predict and redirect immunodominant epitopes in HIV Env, showing improved vaccine antigen design.

bioRxiv · Mar 11, 2026 · PreprintImmunology

Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques

Yasmine Issah, Xintao Hu, John Isaac, Xiaoying Shen, Dominique Davis, Gabriel Ozorowski, Leigh M. Sewall, Shiyu Zhang, Euchong Kang, Kenneth Vuong, Maria L. Dennis, Jui‐Lin Chen, José Manuel Ramos, Anila Yasmeen, Joshua Eudailey, , Ashley N. Nelson

This study compares bnAb precursor responses in infant and juvenile rhesus macaques after germline-targeting HIV Env immunization, finding higher rates in infants.

bioRxiv · May 27, 2025 · PreprintImmunology

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

George Ueda, Aleksandar Antanasijevic, Jorge A. Fallas, William Sheffler, Jeffrey Copps, Daniel Ellis, Geoffrey B. Hutchinson, Adam P. Moyer, Anila Yasmeen, Yaroslav Tsybovsky, Young‐Jun Park, Matthew J. Bick, Banumathi Sankaran, Rebecca A. Gillespie, Philip J. M. Brouwer, , David A. Baker

Designed trimers matched to viral glycoprotein termini yielded tetrahedral, octahedral and icosahedral nanoparticles with cryo-EM-verified structures that display native-like HIV Env, influenza HA and RSV F.

eLife · Aug 3, 2020Peer-reviewedSynthetic Biology✦ In-depth digest