Mammalian cells evacuate and shelter mitochondrial DNA from destruction following hypoxia response-induced mitophagy
Reiko Kamegai, Asato Uenosono, Fumiyo Ikeda, Keisuke Ohta, Kota Yanagitani
The paper shows mammalian cells protect mitochondrial DNA during hypoxia-induced mitophagy by forming large mitochondria that shield mtDNA from degradation.
bioRxiv · Aug 1, 2025 · PreprintCell Biology