Fumiyo Ikeda

This study shows that reduced HOIL-1 activity increases Met1-ubiquitin chains, leading to solid protein aggregates and impaired autophagy in neurodegenerative diseases.

This study identifies LUBEL/RNF31 as a key regulator of T-tubule biogenesis through linear ubiquitination, showing its interaction with Amphiphysin and role in membrane tubulation.

The paper shows mammalian cells protect mitochondrial DNA during hypoxia-induced mitophagy by forming large mitochondria that shield mtDNA from degradation.

This study shows that XIAP promotes autophagosome-lysosome fusion by ubiquitinating autophagy regulators, enhancing autophagic flux.