Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.
Malay Mondal, Windfield S. Swetman, Shazeed-Ul Karim, Sabin Shrestha, Ashe M. Davis, Fengwei Bai, Faqing Huang, Tristan D. Clemons, Vijayaraghavan Rangachari
This study demonstrates that disulfide-cross-linked peptide condensates efficiently deliver various molecular cargos, including DNA and mRNA, into HeLa cells with higher transfection efficiency than commercial agents.
Proceedings of the National Academy of Sciences · Oct 8, 2025Peer-reviewedBiophysics