Tristan D. Clemons

This study identifies disulfide crosslink density as a critical factor in controlling the formation, fluidity, and maturation of cysteine-rich biomolecular condensates.

This paper develops supramolecular polymers to target and degrade α-synuclein, showing reduced protein levels in vitro.

This study demonstrates that disulfide-cross-linked peptide condensates efficiently deliver various molecular cargos, including DNA and mRNA, into HeLa cells with higher transfection efficiency than commercial agents.

This study blends amyloid peptides with poly(ethylene oxide) to create composite mats with enhanced mechanical and biological properties.

This study investigates the role of cysteine residues in biomolecular condensates, showing they function as covalent nodes that tune phase separation through redox-sensitive disulfide bonds.

The paper identifies that poly-GR binds ribosomal RNA and shows that modified rRNA oligonucleotides can mitigate poly-GR toxicity in models of C9orf72 ALS/FTD.