Third generation cephalosporin-induced L-form transition in Shigella sonnei reveals a virulence-survival trade-off underlying persistent infection
Sanjib Das, Arindam Mukherjee, Prolay Halder, Soumalya Banerjee, Supriya Mandal, Nivedita Roy, Ashis Debnath, Sreejani Banerjee, Manjistha Manna, Upama Mandal, Jiro Mitobe, Jeffrey H. Withey, Asish K. Mukhopadhyay, Santasabuj Das, Debaki Ranjan Howlader, Hemanta Koley
This paper shows that Shigella sonnei can transition into L-forms in response to third-generation cephalosporins, gaining survival benefits but losing virulence, leading to persistent infections.
Microbiology Spectrum · Jun 22, 2026Peer-reviewedMicrobiology