B-cell SIGLEC-5 engages T-cell components of the elastin receptor complex (ERC) to suppress inflammatory T-cell cytokines
Christopher J. M. Piper, Clive Metcalfe, Maana Layeghi, Guillem Montamat, Zara Baig, Ashley Ferrier, Lars Nitschke, Diego Catalán, Claudia Mauri
The paper identifies SIGLEC-5 as an inhibitory receptor on B-cells that suppresses T-cell inflammatory cytokines by engaging the elastin receptor complex.
bioRxiv · Jun 29, 2026 · PreprintImmunology