Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer's disease progression.
Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin E. Braunstein, Jonathan P. Ling, Juan Carlos Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li
The paper identifies stage-specific microglia subtypes in Alzheimer's disease using single-cell RNA-sequencing, showing both amyloid-beta and tau pathologies are required for their induction.
bioRxiv · Oct 16, 2021 · PreprintNeuroscience