Seth Blackshaw

The paper identifies an NR2F1-dependent retinoic acid network in mice that regulates retinal specialization and links its disruption to foveal hypoplasia in BBSOAS patients.

The paper reconstructs the evolutionary origins of retinal amacrine cell diversity using transcriptomic data from 24 vertebrate species, identifying 42 orthologous cell types and suggesting a hybrid precursor origin.

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

This paper provides a standardized protocol for isolating and characterizing extracellular vesicles from mouse retinal tissue, improving the study of in vivo EV biology.

JACUZI-SD is a method to induce sleep deprivation in larval zebrafish with minimal stress, reducing total sleep time by 41-64% and eliciting rebound sleep.

This study shows that blocking apoptosis in retinal organoids increases RGC survival but delays their development, highlighting apoptosis's role in regulating RGC quantity and dynamics.

This study investigates the role of Sox8 and Sox9 in retinal Muller glia differentiation and nuclear positioning using genetic and single-cell multiomic approaches.

This study identifies DIO3 as a regulator of photoreceptor development timing and fate stability in human retinal organoids, proposing an hourglass model for developmental progression.

The paper uses fate mapping and 4D modeling to reveal modular growth patterns in the chick forebrain, challenging the prosomere model and proposing a tripartite hypothalamus model.

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

This study identifies the lncRNA Peanut as promoting rod photoreceptor differentiation and neurogenesis by inhibiting Notch signaling and regulating Tox2 expression in retinal progenitor cells.

This study shows that overexpressing Meis1 and Meis2 in postnatal mouse retinal progenitor cells has distinct effects on temporal identity and neurogenesis, without fully reprogramming cell fate.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

This study identifies gene regulatory networks controlling hypothalamic and prethalamic development using single-cell RNA and ATAC sequencing in mice, revealing key transcription factors and their roles in metabolic and cognitive traits.

This study shows cigarette smoke and aging induce degenerative heterogeneity in RPE cells through distinct epigenetic changes, with young RPE showing compensatory responses not seen in aged RPE.

MetaLigand predicts non-peptide ligand-receptor interactions using transcriptomic data, revealing unique NPL profiles in retinal cell types associated with age-related macular degeneration.

This study uses single nucleus RNA-Seq to show increased adipogenesis and IGF-1R pathway alterations in TED orbital fat, suggesting linsitinib as a potential therapeutic.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

The paper identifies an extra-SCN brain oscillator in the lateral amygdala that coordinates cellular and behavioral rhythms through mWAKE/ANKFN1 expression.

This study shows that viral-mediated Oct4 overexpression and Notch inhibition together induce neurogenic competence in mammalian Muller glia, enabling transdifferentiation into bipolar neurons.

This study shows that elevated nuclear TDP-43 causes species-specific exon skipping, which differs from exon skipping seen in TDP-43 loss-of-function, highlighting the need for careful interpretation of TDP-43 overexpression models.

The paper constructs an intercellular communication atlas of the retina, identifying Oprm1 as a neuroprotective factor that enhances RGC survival through ligand-receptor interactions.

The paper compares gene regulatory networks in zebrafish retinal regeneration and development after different neuronal subtype losses, finding both similarities and differences.

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.

This study compares single-cell and single-nucleus RNA-seq in a rabbit PVR model, finding similar gene expression profiles but differences in cell type capture rates and fibrotic cell representation.

This study identifies a BMP signaling wave that drives anteroposterior specification of the tuberal hypothalamus in chicken embryos.

The paper identifies mechanisms that generate M/L cone dominance and suppress S cones in the human foveola using retinal organoids and signaling pathway regulators.