Dong Won Kim

The paper identifies population-specific transcriptional changes in neurons across Alzheimer's disease models and human samples, revealing molecular remodeling not captured by population representation alone.

The paper shows that STAT1 independently controls microglial neutral-lipid content without relying on lipid-handling transcriptional programs.

This study identifies gene regulatory networks controlling hypothalamic and prethalamic development using single-cell RNA and ATAC sequencing in mice, revealing key transcription factors and their roles in metabolic and cognitive traits.

This study uses single nucleus RNA-Seq to show increased adipogenesis and IGF-1R pathway alterations in TED orbital fat, suggesting linsitinib as a potential therapeutic.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

The paper identifies an extra-SCN brain oscillator in the lateral amygdala that coordinates cellular and behavioral rhythms through mWAKE/ANKFN1 expression.

The paper demonstrates the feasibility of using synthetic centromeres in maize to transmit chromosomes across generations through a LexA-CENH3 tethering approach.

This study identifies a BMP signaling wave that drives anteroposterior specification of the tuberal hypothalamus in chicken embryos.

This study uses single-cell RNA-Seq to analyze early chick hypothalamic development, revealing that hypothalamic cells originate from prethalamic-like progenitors and identifying novel molecular regulators.

This study shows that NrCAM regulates adult hypothalamic tanycytes, affecting their numbers and marker expression, but with only subtle metabolic consequences.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

The paper identifies stage-specific microglia subtypes in Alzheimer's disease using single-cell RNA-sequencing, showing both amyloid-beta and tau pathologies are required for their induction.

This study shows that deleting Ptbp1 in adult retinal Muller glia and brain astrocytes does not convert glia into neurons, using genetic lineage tracing, scRNA-Seq, and electrophysiology.

The paper uses single-cell RNA-Seq to map transcriptional programs in synovial joint development, identifying a progenitor population and the role of FGF signaling in chondrocyte fate.

A multi-genome analysis of maize reveals previously unknown variation in gene content, genome structure, and methylation.

The paper uses transcriptomic analysis to compare gene expression in control and TAO patients' orbital fat and differentiating orbital fibroblasts, identifying IGF-1R and Wnt signaling pathway differences.

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.

The paper identifies two developmental origins of thalamic inhibitory interneurons in mice and shows their distribution in the marmoset thalamus.

This study identifies molecular mechanisms controlling the development of hypothalamic GABAergic neurons expressing Lhx6, showing their distinct regulatory networks compared to cortical interneurons.

The paper characterizes mWake expression in the adult mouse brain, identifying its presence in neurons and non-neuronal cells across multiple brain regions and providing single-cell RNA sequencing analysis of hypothalamic mWake+ cells.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

The paper investigates the role of somatostatin signaling via Sstr2 in retinal neurogenesis using scRNA-Seq and in vivo experiments, finding it inhibits photoreceptor generation and affects progenitor dynamics.

The paper constructs a single-cell transcriptional atlas of synovial joint progenitors from E12.5 to E15.5 in mice to uncover transcriptional programs and cell interactions during joint development.

The paper uses scRNA-Seq to analyze mouse hypothalamic development, identifying gene expression trajectories and regional subdivisions, and reveals Nkx2.1 as a negative regulator of prethalamic identity.

This study identifies a conserved clock-regulated neural network in mice and Drosophila that controls arousal and sleep, showing that mWake+ cells are critical for circadian-dependent neural excitability.

PanoView is an iterative clustering method for scRNA-seq data that outperforms existing methods in detecting major and rare cell types without parameter tuning.

This study investigates tanycytic leptin receptor expression and function in mice, finding no detectable LepR in tanycytes and no effect of their deletion on hypothalamic leptin signaling.

This study shows Foxd1 is required for sustained expression of genes in mature anterior hypothalamic neurons, but not for initial patterning.