Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy
V.S.S. Abhinav Ayyadevara, Shikha Gaur, Ashley Paik, Ria Perencsik, Monika Maria Toma, Gerald B. W. Wertheim, Huimin Geng, Tomasz Skórski, Srividya Swaminathan, Christian Hurtz
This study identifies BRG1 as a critical target in Ph-like B-ALL, showing its inhibition leads to cell cycle arrest and improved survival in preclinical models.
bioRxiv · Jul 8, 2025 · PreprintCancer Biology