Srividya Swaminathan

Sympathetic neurons control adaptive immunity in response to Streptococcus pneumoniae infection by regulating T cell and B cell effector function

This study shows that sympathetic neurons regulate T cell and B cell responses to Streptococcus pneumoniae infection, enhancing IgG production and bacterial clearance.

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia

The paper identifies RAG-mediated structural variants as a risk factor for relapse in pediatric B-ALL and T-ALL, independent of MRD status.

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells and averts lupus nephritis

This study shows that knocking down the long isoform of the prolactin receptor reduces pathogenic immune cells and prevents lupus nephritis in SLE-prone mice.

Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy

This study identifies BRG1 as a critical target in Ph-like B-ALL, showing its inhibition leads to cell cycle arrest and improved survival in preclinical models.