ENaC contributes to macrophage dysfunction in cystic fibrosis
John Moran, Courtney Pugh, Nevian Brown, Ashley Thomas, Shuzhong Zhang, Emily McCauley, Amelia Cephas, Chandra L. Shrestha, Santiago Partida‐Sánchez, Shasha Bai, Emanuela M. Bruscia, Benjamin T. Kopp
This study shows ENaC is overexpressed in CF macrophages and contributes to their dysfunction, with ENaC inhibition improving immune function and reducing inflammation.
American Journal of Physiology-Lung Cellular and Molecular Physiology · Jun 2, 2025Peer-reviewedImmunology