Emanuela M. Bruscia

This paper identifies I-152 as a compound that disrupts Pseudomonas aeruginosa biofilm formation and reduces LPS-induced inflammation through redox cycling inhibition and anti-inflammatory effects.

This study shows ENaC is overexpressed in CF macrophages and contributes to their dysfunction, with ENaC inhibition improving immune function and reducing inflammation.

This study shows chronic lung inflammation in a CF mouse model increases myeloid bias in hematopoietic stem cells, which persists even after inflammation resolves.