ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP)
Jimi L. Rosenkrantz, Sanaz Raghib, J. Elias Brandorff, Ashni Kapadia, Christine A. Vaine, D. Cristopher Bragg, Grace Farmiloe, Frank M. J. Jacobs
This study shows that ZNF91 represses the XDP-SVA insertion and mitigates the molecular phenotype of XDP, with age-related ZNF91 expression decline contributing to disease progression.
bioRxiv · Oct 20, 2023 · PreprintNeuroscience