Connexin50 hemichannels are opened by CO2: implications for lens physiology
Alexandra Lovatt, Frederick Bibra, Ashvini Wijayapala, Macy Mui, Jack Butler, Nicholas Dale
This study shows that CO2 opens Cx50 hemichannels in lens cells, allowing lactate and glutamate passage, and that this process is regulated by specific residues and involves Ca2+ influx.
Frontiers in Physiology · Jul 22, 2026Peer-reviewedCell Biology