Nicholas Dale

The paper identifies a Cx26+ neural crest lineage that emerges in mid-life and mediates enhanced CO2 responses in the brainstem, impacting breathing and metabolism.

This study shows that CO2 opens Cx50 hemichannels in lens cells, allowing lactate and glutamate passage, and that this process is regulated by specific residues and involves Ca2+ influx.

The paper identifies connexins, aquaporins, and carbonic anhydrase 2 as essential components for cellular CO2 sensing, demonstrating their combined necessity through experimental and simulation studies.

This study identifies connexins in invertebrate genomes, showing their evolutionary origin predates chordates and functional similarity to vertebrate connexins in innate immunity.

The paper demonstrates that Cx43 hemichannels open in response to CO2, resolving a discrepancy between in vivo and in vitro studies.

The paper solves the structure of Connexin26 from Lepidosiren paradoxa at high CO2 levels, revealing an open conformation stabilized by detergent binding between TM3 and TM4.

This study investigates permselectivity of connexin hemichannels for small molecules, finding that selectivity varies among connexins and is influenced by factors beyond molecular size.

This study identifies Cx26 hemichannels as a CO2 sensor in serotonergic neurons that mediates hypercapnic arousal by enabling serotonin release.

The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.

This study investigates changes in respiratory chemosensitivity in mice with chronic epilepsy, finding reduced adaptive responses to hypercapnia and shifts in neuronal response patterns over time.

The paper uses imaging to study neural activity in brainstem regions during CO2 exposure in mice, revealing distinct roles for RTN, Raphe, and pFL in respiratory chemosensitivity.

The paper shows that CO2-binding to Cx26 in glial cells of the medulla oblongata contributes significantly to ventilatory responses to CO2.