Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis
C.-S. Park, Kyung In Baek, Ruei-Chun Hung, Leandro Choi, Kiyoung Jeong, Paul Kim, Andrew Keunho Jahng, Jung‐Hyun Kim, Mostafa Meselhe, Ashwin Kannan, Chien-Ling Chou, Dong Won Kang, Eun Ju Song, Yerin Kim, Jay Aaron Bowman-Kirigin, , Hanjoong Jo
This study validates the two-hit hypothesis showing disturbed flow and hypercholesterolemia together reprogram endothelial cells to immune-like and foam cells during atherogenesis.
bioRxiv · Mar 6, 2025 · PreprintCell Biology