Dong Won Kang

This study identifies HEG1 as a flow-sensitive protein that regulates eNOS activity, preventing endothelial dysfunction, hypertension, and atherosclerosis.

This study validates the two-hit hypothesis showing disturbed flow and hypercholesterolemia together reprogram endothelial cells to immune-like and foam cells during atherogenesis.

The paper describes the development of a corrected Poldip2 floxed mouse model, identifies a mutation in initial models, and characterizes the effects of Poldip2 knockout in mice.