Gerard Pasterkamp

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

The paper uses CROP-seq to identify histone modifying enzymes regulating inflammatory macrophage activation, finding Kdm5c modulates inflammatory responses by balancing baseline and inducible activation.

The paper integrates multi-modal omics data to identify therapeutic pathways in atherosclerosis for coronary heart disease, highlighting amino acid metabolism and 16 relevant proteins.

The paper identifies gene signatures of endothelial-to-mesenchymal transition in human atherosclerotic tissue using combined in vitro and single-cell transcriptomic data.

This study validates the two-hit hypothesis showing disturbed flow and hypercholesterolemia together reprogram endothelial cells to immune-like and foam cells during atherogenesis.

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

The paper uses proteogenomic integration to identify CXCL10 as a mediator of IL-6 signaling effects on atherosclerosis, showing its association with cardiovascular disease risk and lesion characteristics.

The paper maps sex-dependent gene activity across 24 human tissues using RNA-sequencing data and identifies sex-biased genes and pathways.

This study investigates the causal relationship between DNA methylation of shear stress-associated genes in carotid plaques and cardiovascular disease risk using Mendelian randomisation, finding no significant association.

The paper identifies a genetic variant associated with increased carotid plaque vulnerability but not with cardiovascular disease risk in humans.

The paper investigates whether reduced sclerostin expression is linked to cardiovascular events by analyzing genetic variants and immunohistochemical data from atherosclerotic plaques.

This study examines the association between family history and polygenic risk scores with secondary cardiovascular events in patients undergoing carotid endarterectomy, finding both factors independently increase risk.

The paper investigates the association between genetic risk variants and clinical features of abdominal aortic aneurysms using a biobank cohort, finding a weak polygenic correlation with aneurysm diameter but no clear individual variant associations.