Breastmilk antibody isotypes differentially protect against neonatal rotavirus infection and modulate the timing and clonal architecture of offspring B cell responses
Konjit Getachew Muleta, Simone Isling Pærregaard, Sharné van Dijl, Giorgia Montano, Dasiel Castellanos Pérez, Rachael FitzPatrick, Asma Sadik Mustafa, Niklas Krausse, Manar Alyamani, Gina Lindberg, Gabriel Núñez, Joan Yuan, Katharina Lahl
This study shows maternal IgA protects against neonatal rotavirus infection while maternal IgG delays humoral immunity development, demonstrating passive immunity's dual role in immediate protection and long-term immune education.
bioRxiv · Sep 20, 2024 · PreprintImmunology