Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection
Asmita Panthi, Max Ferretti, Olivia Howard, Swechha Mainali Pokharel, Rhiannon McCracken, Simon Boudreault, Mathieu Quesnel-Vallières, Qin Li, Sara R. Cherry, Kristen W. Lynch
This study identifies an alternative splicing mechanism in IRF7 that generates a protein isoform with enhanced transcriptional activity, leading to increased resistance to viral infection.
Cell Reports · Aug 19, 2025Peer-reviewedMolecular Biology