Author

Swechha Mainali Pokharel

University of PennsylvaniaORCID 0000-0002-9555-5265Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Sara Cherry· 2 shared Sara R. CherryiD· 2 shared Adam J. GilbertseniD· 1 shared Anne Rivas· 1 shared Arno Wuenschmann· 1 shared Asmita Panthi· 1 shared Caroline BartmaniD· 1 shared Celia Torres-AranciviaiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Sara Cherry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A mammalian fibroblast zoo reveals barriers to cross-species virus replication and differential regulation of antiviral immunity

Clayton K. Mickelson, Mark Salnikov, Frances K. Shepherd, Lauren M. Pross, Georgia McClain, Swechha Mainali Pokharel, H. Heinrich Hoffmann, Timo Schoon, Girish Pulinkala, Nakarin Pamornchainavakul, Kayla Hoffman, Cera A. McDonald, Esther Vogt, Tristan T. Neal, Adam J. Gilbertsen, , Ryan A. Langlois

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

bioRxiv · Nov 6, 2026 · PreprintImmunology

A dynamic molecular glue targets a plastic MDA5 filament interface to stimulate innate immunity

闫丽娟, 闫丽娟, Ziqing Ye, Swechha Mainali Pokharel, Tiffany Y. T. Hsu, Celia Torres-Arancivia, Koji Haratani, Elena V. Ivanova, Cloud Peter Paweletz, Sara Cherry, David Allen Barbie, Sun Hur

This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.

bioRxiv · Oct 20, 2026 · PreprintImmunology

Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite

Helen A. Jordan, Joseph A. Tandurella, Vineeth Vengayil, Tanay S. Parnaik, Swechha Mainali Pokharel, Kathleen R. Mulka, Sara R. Cherry, E. John Wherry, Caroline Bartman

The paper identifies soluble sialic acid as a conserved biomarker of inflammation through metabolomics in mouse tissues and cultured macrophages.

Journal of Biological Chemistry · Sep 7, 2026Peer-reviewedBiochemistry

Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection

Asmita Panthi, Max Ferretti, Olivia Howard, Swechha Mainali Pokharel, Rhiannon McCracken, Simon Boudreault, Mathieu Quesnel-Vallières, Qin Li, Sara R. Cherry, Kristen W. Lynch

This study identifies an alternative splicing mechanism in IRF7 that generates a protein isoform with enhanced transcriptional activity, leading to increased resistance to viral infection.

Cell Reports · Aug 19, 2025Peer-reviewedMolecular Biology